New research suggests that individuals who stop using new weight-loss injections like semaglutide or tirzepatide can put back on reduced body mass at a significantly accelerated pace than those who halt traditional diet and exercise regimens.
Findings released in a leading health publication demonstrates that while obese individuals often shed a large proportion of their total mass while on the medication, the weight comes back at an average rate of nearly a kilo each month upon discontinuation.
"Individuals using these drugs must be informed of the potential of quick weight regain when the treatment is stopped," warns researcher Dr. Susan Jebb.
That rate of recovery means a reversion to starting mass in about 18 months.
Weighing Approaches
The analysis, which reviewed 37 of studies involving thousands of participants, contrasted the effects of these new drugs with other pills.
The team note that people who lose weight through lifestyle changes alone typically see a slower weight regain—perhaps 0.1 kg a month—once they finish.
The Reason for the Rapid Rebound
Experts suggest the way of the jabs is key to understanding the amplified regain.
The injections mimic a natural hormone called GLP-1, which helps regulate hunger.
"Artificially providing the hormone levels several times higher than normal might result in the system to generate a reduced amount of its endogenous GLP-1, and could reduce responsiveness to its actions," said Dr. Adam Collins, a dietetics researcher.
"Withdrawal of this medication leads to appetite is no longer kept in check, making excessive eating far more likely."
An Ongoing Condition?
Medical guidelines advise the injections for individuals with obesity-related medical conditions, alongside recommended diet and exercise modifications.
A number of clinicians say that, due to the likelihood of weight regain, the therapy might need to be life-long.
This opinion is echoed by drug manufacturers, who state that the results "highlight the persistent nature of excess weight," comparing it to managing diseases like diabetes.
Patient Experiences
People who have stopped the jabs explain a intense resurgence of cravings.
"I experienced something activating and you're instantly ravenous," said an individual.
This challenge is worsened if users have not adopted sustainable dietary or behavioural changes during treatment.
Significant Use
Survey data show that a significant number of people in the UK have used these injections in the past year, with demand remaining high.
- Use is greater among females than males.
- The 40s and 50s age group shows the greatest usage rates.
- Many obtain the drugs through private prescriptions rather than public health services.
Ultimately, experts stress that while the jabs are powerful agents for shedding pounds, they are not a magic cure and maintained weight loss likely depends on ongoing behavioural support.
